Assay Detail

CHEMBL5539864

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Binding

Inhibition of Hepatitis C virus genotype 5 NS4B

ChEMBL ↗

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Target

Non-structural protein 4b (CHEMBL6066153) ↗

Open DB target context

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Non-structural protein 4b (CHEMBL6066153) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Non-structural protein 4b

CHEMBL6066153

Anchored from Assay target.

Protein identity Non-structural protein 4b

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepacivirus hominis
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Non-structural protein 4b (CHEMBL6066153) ↗

Type	SINGLE PROTEIN
Organism	Hepacivirus hominis

Publication

Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?

Martino SD, Petri GL, De Rosa M.
J Med Chem (2024) 67 : 885 -921
PubMed 38179950 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL258734	DANOPREVIR	3.0	1	9.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL258734	DANOPREVIR	IC50	=	0.2	nM	9.70