Assay Detail
Binding
CHEMBL5539889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Hepatitis C virus NS3 protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.57 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566838 | — | — | 1 | 7.96 |
| CHEMBL5593902 | — | — | 1 | 7.57 |
| CHEMBL5573211 | — | — | 1 | 6.40 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 5.52 |
| CHEMBL2370476 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566838 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5593902 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5573211 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL297884 | CILUPREVIR | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2370476 | — | IC50 | = | 4000.0 | nM | 5.40 |