Assay Detail
Binding
CHEMBL5539892
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Binding affinity to full length Hepatitis C virus genotype 1b NS4B expressed in Escherichia coli assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 10.35 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063089 | — | — | 1 | 10.70 |
| CHEMBL5568760 | — | — | 1 | 10.30 |
| CHEMBL1956820 | GS-9256 | 2.0 | 1 | 10.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063089 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL5568760 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL1956820 | GS-9256 | Ki | = | 0.089 | nM | 10.05 |