Assay Detail
Binding
CHEMBL5540174
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Competitive binding affinity to His-tagged VHL/Elongin C/Elongin B (unknown origin) by FP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS<sup>G12D</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.12 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570147 | — | — | 1 | 6.52 |
| CHEMBL4565531 | — | — | 1 | 6.46 |
| CHEMBL5562553 | — | — | 1 | 6.39 |
| CHEMBL5595377 | — | — | 1 | 6.04 |
| CHEMBL5592984 | — | — | 1 | 5.67 |
| CHEMBL5565363 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570147 | — | IC50 | = | 299.1 | nM | 6.52 |
| CHEMBL4565531 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL5562553 | — | IC50 | = | 406.6 | nM | 6.39 |
| CHEMBL5595377 | — | IC50 | = | 908.0 | nM | 6.04 |
| CHEMBL5592984 | — | IC50 | = | 2159.0 | nM | 5.67 |
| CHEMBL5565363 | — | IC50 | = | 2274.0 | nM | 5.64 |