Assay Detail
Functional
CHEMBL5540232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human 92-1 cells incubated for 72 hrs by microplate reader analysis
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 92-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.68 | 7.96 |
| IC50 | 3 | 6.29 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3982497 | — | — | 1 | 7.96 |
| CHEMBL3966643 | — | — | 1 | 7.85 |
| CHEMBL3966595 | — | — | 1 | 7.66 |
| CHEMBL5573642 | — | — | 1 | 7.44 |
| CHEMBL3957149 | — | — | 1 | 7.22 |
| CHEMBL3943147 | — | — | 1 | 7.18 |
| CHEMBL5592487 | — | — | 1 | 6.85 |
| CHEMBL3890986 | — | — | 1 | 6.85 |
| CHEMBL3946659 | — | — | 1 | 6.82 |
| CHEMBL3982723 | DAROVASERTIB | 2.0 | 1 | 6.77 |
| CHEMBL3915489 | — | — | 1 | 6.75 |
| CHEMBL5566264 | — | — | 1 | 6.64 |
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | 6.60 |
| CHEMBL3924825 | — | — | 1 | 6.21 |
| CHEMBL3957715 | — | — | 1 | 6.16 |
| CHEMBL3950697 | — | — | 1 | 6.11 |
| CHEMBL5564760 | — | — | 1 | 5.86 |
| CHEMBL5565713 | — | — | 1 | 5.76 |
| CHEMBL3965722 | — | — | 1 | 5.55 |
| CHEMBL5571382 | — | — | 1 | 5.44 |
| CHEMBL5591535 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3982497 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3966643 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3966595 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5573642 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3957149 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3943147 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5592487 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3890986 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3946659 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3982723 | DAROVASERTIB | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3915489 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5566264 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL565612 | SOTRASTAURIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3924825 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3957715 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3950697 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5564760 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5565713 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3965722 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5571382 | — | EC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL5591535 | — | IC50 | = | 3700.0 | nM | 5.43 |