Assay Detail
Toxicity
CHEMBL5540233
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Inhibition of FLT3 (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.43 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566264 | — | — | 1 | 7.52 |
| CHEMBL3957715 | — | — | 1 | 7.51 |
| CHEMBL3982497 | — | — | 1 | 7.48 |
| CHEMBL3943147 | — | — | 1 | 7.02 |
| CHEMBL3957149 | — | — | 1 | 6.85 |
| CHEMBL5573642 | — | — | 1 | 6.64 |
| CHEMBL3966643 | — | — | 1 | 6.64 |
| CHEMBL5571382 | — | — | 1 | 5.52 |
| CHEMBL3924825 | — | — | 1 | 5.39 |
| CHEMBL3915489 | — | — | 1 | 5.07 |
| CHEMBL3890986 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566264 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3957715 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3982497 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3943147 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3957149 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5573642 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3966643 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5571382 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3924825 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3915489 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL3890986 | — | IC50 | = | 8700.0 | nM | 5.06 |