Assay Detail
Toxicity
CHEMBL5540234
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Inhibition of GSK3beta (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.25 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573642 | — | — | 1 | 8.00 |
| CHEMBL3982497 | — | — | 1 | 7.72 |
| CHEMBL3957715 | — | — | 1 | 7.39 |
| CHEMBL5566264 | — | — | 1 | 6.28 |
| CHEMBL3924825 | — | — | 1 | 6.15 |
| CHEMBL3943147 | — | — | 1 | 5.57 |
| CHEMBL3957149 | — | — | 1 | 5.54 |
| CHEMBL3915489 | — | — | 1 | 5.47 |
| CHEMBL3890986 | — | — | 1 | 5.21 |
| CHEMBL5571382 | — | — | 1 | 5.16 |
| CHEMBL3966643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573642 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3982497 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3957715 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5566264 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3924825 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3943147 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3957149 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3915489 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL3890986 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5571382 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3966643 | — | IC50 | > | 10000.0 | nM | - |