Assay Detail
Functional
CHEMBL5540392
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Antimalarial activity against Plasmodium falciparum harboring AcAS A597V mutation assessed as reduction in parasitemia incubated for 72 hrs by SYBR green I dye based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.26 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431809 | — | — | 1 | 8.96 |
| CHEMBL3325608 | — | — | 1 | 8.38 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.29 |
| CHEMBL5574442 | — | — | 1 | 7.39 |
| CHEMBL586032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431809 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3325608 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5574442 | — | EC50 | = | 40.5 | nM | 7.39 |
| CHEMBL586032 | — | EC50 | > | 50000.0 | nM | - |