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Assay Detail

CHEMBL5540516

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.
Qin L, Cheng X, Wang S, Gong G, Su H, Huang H, Chen T, Damdinjav D, Dorjsuren B, Li Z, Qiu Z, Bian J.
J Med Chem (2024) 67 : 988 -1007
PubMed 38217503 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.83 5.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5572948 1 5.23
CHEMBL5575983 1 4.99
CHEMBL5570488 1 4.99
CHEMBL5570436 1 4.91
CHEMBL5567324 1 4.90
CHEMBL5573092 1 4.89
CHEMBL5563389 1 4.88
CHEMBL5568646 1 4.87
CHEMBL5591795 1 4.86
CHEMBL5571540 1 4.84
CHEMBL5572093 1 4.83
CHEMBL5571111 1 4.83
CHEMBL5569240 1 4.82
CHEMBL5570466 1 4.82
CHEMBL5592732 1 4.72
CHEMBL3754053 1 4.69
CHEMBL5565527 1 4.61
CHEMBL5591185 1 4.59
CHEMBL5562772 1 4.59
CHEMBL5569333 1 -
CHEMBL5573607 1 -
CHEMBL5571756 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5572948 IC50 = 5830.0 nM 5.23
CHEMBL5575983 IC50 = 10160.0 nM 4.99
CHEMBL5570488 IC50 = 10350.0 nM 4.99
CHEMBL5570436 IC50 = 12450.0 nM 4.91
CHEMBL5567324 IC50 = 12720.0 nM 4.90
CHEMBL5573092 IC50 = 13010.0 nM 4.89
CHEMBL5563389 IC50 = 13160.0 nM 4.88
CHEMBL5568646 IC50 = 13400.0 nM 4.87
CHEMBL5591795 IC50 = 13720.0 nM 4.86
CHEMBL5571540 IC50 = 14330.0 nM 4.84
CHEMBL5572093 IC50 = 14830.0 nM 4.83
CHEMBL5571111 IC50 = 14730.0 nM 4.83
CHEMBL5569240 IC50 = 15180.0 nM 4.82
CHEMBL5570466 IC50 = 14980.0 nM 4.82
CHEMBL5592732 IC50 = 19230.0 nM 4.72
CHEMBL3754053 IC50 = 20460.0 nM 4.69
CHEMBL5565527 IC50 = 24340.0 nM 4.61
CHEMBL5591185 IC50 = 25610.0 nM 4.59
CHEMBL5562772 IC50 = 25460.0 nM 4.59
CHEMBL5569333 IC50 > 50000.0 nM -
CHEMBL5573607 IC50 > 50000.0 nM -
CHEMBL5571756 IC50 > 50000.0 nM -