Assay Detail
Functional
CHEMBL5540577
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Antiproliferative activity against human NSCLC cells cultured as 2862 organoids assessed as cell viability incubated for 96 hrs by Celltiter-glo viability assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NSCLC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.41 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572948 | — | — | 1 | 5.54 |
| CHEMBL5570488 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572948 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5570488 | — | IC50 | = | 5210.0 | nM | 5.28 |