Assay Detail
Binding
CHEMBL5540883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERK phosphorylation in wild type human BJ cells incubated for 1 hr by HTRF analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095099 | EXARAFENIB | 2.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095099 | EXARAFENIB | EC50 | = | 7963.0 | nM | 5.10 |