Assay Detail
Binding
CHEMBL5540955
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Inhibition of recombinant human sEH using PHOME as substrate preincubated for 10 mins followed by substrate addition by fluorescence based assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.14 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5564589 | — | — | 1 | 9.96 |
| CHEMBL5590604 | — | — | 1 | 9.74 |
| CHEMBL5573866 | — | — | 1 | 9.64 |
| CHEMBL5571161 | — | — | 1 | 9.60 |
| CHEMBL5570637 | — | — | 1 | 9.60 |
| CHEMBL5571794 | — | — | 1 | 9.44 |
| CHEMBL4869434 | — | — | 1 | 9.40 |
| CHEMBL5571076 | — | — | 1 | 9.40 |
| CHEMBL5567500 | — | — | 1 | 9.40 |
| CHEMBL5591117 | — | — | 1 | 9.40 |
| CHEMBL5571505 | — | — | 1 | 9.29 |
| CHEMBL5564312 | — | — | 1 | 9.28 |
| CHEMBL5569830 | — | — | 1 | 9.25 |
| CHEMBL5592524 | — | — | 1 | 9.22 |
| CHEMBL5573004 | — | — | 1 | 9.15 |
| CHEMBL5563806 | — | — | 1 | 9.00 |
| CHEMBL5570840 | — | — | 1 | 9.00 |
| CHEMBL5574790 | — | — | 1 | 8.96 |
| CHEMBL5571752 | — | — | 1 | 8.80 |
| CHEMBL5574426 | — | — | 1 | 8.77 |
| CHEMBL5567303 | — | — | 1 | 8.70 |
| CHEMBL5566384 | — | — | 1 | 8.60 |
| CHEMBL5564705 | — | — | 1 | 8.52 |
| CHEMBL5570460 | — | — | 1 | 8.21 |
| CHEMBL5564613 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5564589 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5590604 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL5573866 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL5571161 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5570637 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5571794 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL4869434 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5571076 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5567500 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5591117 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5571505 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL5564312 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL5569830 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL5592524 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5573004 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5563806 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5570840 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5574790 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5571752 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5574426 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5567303 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5566384 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5564705 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5570460 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5564613 | — | IC50 | = | 6.3 | nM | 8.20 |