Assay Detail
Binding
CHEMBL5540961
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Dual-Targeting Inhibitors of sEH and HDAC6 for the Treatment of Neuropathic Pain and Lipopolysaccharide-Induced Mortality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.19 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567303 | — | — | 1 | 8.30 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.85 |
| CHEMBL5592524 | — | — | 1 | 7.82 |
| CHEMBL5570460 | — | — | 1 | 7.77 |
| CHEMBL356769 | TUBACIN | — | 1 | 7.72 |
| CHEMBL5564312 | — | — | 1 | 7.33 |
| CHEMBL5564613 | — | — | 1 | 6.45 |
| CHEMBL5574790 | — | — | 1 | 6.05 |
| CHEMBL5571161 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567303 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5592524 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5570460 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL356769 | TUBACIN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5564312 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5564613 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL5574790 | — | IC50 | = | 884.0 | nM | 6.05 |
| CHEMBL5571161 | — | IC50 | = | 3440.0 | nM | 5.46 |