Assay Detail
Functional
CHEMBL5541146
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Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.45 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5563252 | — | — | 1 | 7.05 |
| CHEMBL5563126 | — | — | 1 | 6.68 |
| CHEMBL1241855 | RIGOSERTIB | 3.0 | 1 | 6.43 |
| CHEMBL5573899 | — | — | 1 | 5.76 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.48 |
| CHEMBL5583720 | — | — | 1 | 5.43 |
| CHEMBL5579672 | — | — | 1 | 5.22 |
| CHEMBL5574194 | — | — | 1 | 5.13 |
| CHEMBL5574395 | — | — | 1 | 5.07 |
| CHEMBL5569054 | — | — | 1 | 5.03 |
| CHEMBL5595107 | — | — | 1 | 4.95 |
| CHEMBL5562713 | — | — | 1 | 4.89 |
| CHEMBL5570354 | — | — | 1 | 4.78 |
| CHEMBL5564383 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5563252 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5563126 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1241855 | RIGOSERTIB | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5573899 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL5583720 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL5579672 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL5574194 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL5574395 | — | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL5569054 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL5595107 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5562713 | — | IC50 | = | 12820.0 | nM | 4.89 |
| CHEMBL5570354 | — | IC50 | = | 16660.0 | nM | 4.78 |
| CHEMBL5564383 | — | IC50 | = | 35480.0 | nM | 4.45 |