Assay Detail
Binding
CHEMBL5541171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PLK1 (unknown origin)
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.27 | 7.82 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241855 | RIGOSERTIB | 3.0 | 1 | 7.82 |
| CHEMBL5563252 | — | — | 2 | 7.75 |
| CHEMBL5563126 | — | — | 2 | 7.69 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241855 | RIGOSERTIB | IC50 | = | 15.16 | nM | 7.82 |
| CHEMBL5563252 | — | IC50 | = | 17.85 | nM | 7.75 |
| CHEMBL5563126 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1596.78 | nM | 5.80 |
| CHEMBL5563126 | — | Inhibition | - | % | - | |
| CHEMBL5563252 | — | Inhibition | - | % | - |