Assay Detail
Functional
CHEMBL5541327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ferroptosis in human NCI-H522 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.95 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569478 | — | — | 1 | 8.52 |
| CHEMBL1499544 | — | — | 1 | 7.85 |
| CHEMBL1951048 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569478 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1499544 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1951048 | — | IC50 | = | 33.0 | nM | 7.48 |