Assay Detail
Functional
CHEMBL5541349
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Antiproliferative activity against human ICC13-7 cells assessed as inhibition of cell growth incubated for 3 days by Cell-titer glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ICC13-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.66 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | 8.96 |
| CHEMBL5589734 | — | — | 1 | 8.85 |
| CHEMBL3701238 | FUTIBATINIB | 4.0 | 1 | 8.74 |
| CHEMBL5314537 | RESIGRATINIB | 2.0 | 1 | 8.70 |
| CHEMBL5571671 | — | — | 1 | 8.66 |
| CHEMBL4297522 | PEMIGATINIB | 4.0 | 1 | 8.59 |
| CHEMBL1852688 | INFIGRATINIB | 4.0 | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545376 | ERDAFITINIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5589734 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3701238 | FUTIBATINIB | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5314537 | RESIGRATINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5571671 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4297522 | PEMIGATINIB | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1852688 | INFIGRATINIB | IC50 | = | 7.6 | nM | 8.12 |