Assay Detail
ADMET
CHEMBL5541708
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Inhibition of CYP3A4/5 in human liver microsomes incubated for 15 mins by LC-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Identification of Piperazinyl-Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.70 |
| CHEMBL5570406 | — | — | 1 | 5.42 |
| CHEMBL5571836 | — | — | 1 | 4.81 |
| CHEMBL5572540 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5570406 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5571836 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL5572540 | — | IC50 | = | 18100.0 | nM | 4.74 |