Assay Detail
Functional
CHEMBL5543205
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Anti-inflammatory activity in LPS-stimulated mouse B16-F10 cells assessed as reduction in TNFalpha production measured for 12 hrs by ELISA method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201647 | — | — | 1 | 5.89 |
| CHEMBL476121 | XANTHOMICROL | — | 1 | 5.42 |
| CHEMBL312790 | SIDERITIFLAVONE | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201647 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL476121 | XANTHOMICROL | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL312790 | SIDERITIFLAVONE | IC50 | = | 5600.0 | nM | 5.25 |