Assay Detail
Functional
CHEMBL5543255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.50 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561780 | UGONIN T | — | 1 | 6.60 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.96 |
| CHEMBL5571019 | — | — | 1 | 5.66 |
| CHEMBL562706 | UGONIN Q | — | 1 | 5.55 |
| CHEMBL9352 | NARINGENIN | — | 1 | 5.48 |
| CHEMBL5571619 | — | — | 1 | 5.24 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561780 | UGONIN T | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5571019 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL562706 | UGONIN Q | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5571619 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 95000.0 | nM | 4.02 |