Assay Detail
Functional
CHEMBL5543307
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Anti-inflammatory activity in mouse macrophages extracted from abdominal activity assessed as inhibition of LPS-induced nitric oxide production
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.22 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428628 | — | — | 1 | 5.69 |
| CHEMBL5409443 | — | — | 1 | 5.61 |
| CHEMBL5583999 | — | — | 1 | 5.33 |
| CHEMBL400361 | VIRIDIFLORIN | — | 1 | 5.27 |
| CHEMBL5566184 | — | — | 1 | 5.17 |
| CHEMBL172350 | EUPAFOLIN | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428628 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5409443 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL5583999 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL400361 | VIRIDIFLORIN | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL5566184 | — | IC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL172350 | EUPAFOLIN | IC50 | = | 60000.0 | nM | 4.22 |