Assay Detail
Binding
CHEMBL5543336
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Inhibition of human recombinant HDAC1 using Ac-RHKK(Acetyl)-AMC peptide as fluorogenic substrate pre-incubated for 30 mins followed by substrate addition and measured for 60 mins by fluorescence based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.79 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788954 | — | — | 1 | 8.70 |
| CHEMBL4460552 | — | — | 1 | 8.40 |
| CHEMBL4597954 | — | — | 1 | 8.30 |
| CHEMBL4635479 | — | — | 1 | 7.35 |
| CHEMBL5201623 | — | — | 1 | 7.09 |
| CHEMBL5570728 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788954 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4460552 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4597954 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4635479 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5201623 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5570728 | — | IC50 | = | 130.0 | nM | 6.89 |