Assay Detail
Binding
CHEMBL5543345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) using ArgHisLysLys(Ac) as substrate pre-incubated for 1 hr and measured after 1 hr by fluorescence based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.83 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595227 | — | — | 1 | 7.96 |
| CHEMBL5564305 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595227 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5564305 | — | IC50 | = | 2000.0 | nM | 5.70 |