Assay Detail
Functional
CHEMBL5543543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI-H446 cells and decreased in vivo toxicity in Caenorhabditis elegans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.47 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591844 | — | — | 1 | 5.94 |
| CHEMBL5574487 | — | — | 1 | 5.86 |
| CHEMBL5572615 | — | — | 1 | 5.76 |
| CHEMBL5572354 | — | — | 1 | 5.76 |
| CHEMBL5564176 | — | — | 1 | 5.75 |
| CHEMBL5570584 | — | — | 1 | 5.74 |
| CHEMBL5572391 | — | — | 1 | 5.71 |
| CHEMBL5569053 | — | — | 1 | 5.69 |
| CHEMBL5589959 | — | — | 1 | 5.65 |
| CHEMBL5575016 | — | — | 1 | 5.65 |
| CHEMBL5571190 | — | — | 1 | 5.63 |
| CHEMBL5572496 | — | — | 1 | 5.62 |
| CHEMBL5573484 | — | — | 1 | 5.62 |
| CHEMBL5566260 | — | — | 1 | 5.61 |
| CHEMBL3621411 | — | — | 1 | 5.57 |
| CHEMBL5591928 | — | — | 1 | 5.57 |
| CHEMBL5570489 | — | — | 1 | 5.57 |
| CHEMBL5572839 | — | — | 1 | 5.56 |
| CHEMBL5565618 | — | — | 1 | 5.54 |
| CHEMBL5591544 | — | — | 1 | 5.52 |
| CHEMBL5575608 | — | — | 1 | 5.50 |
| CHEMBL5564184 | — | — | 1 | 5.47 |
| CHEMBL5573289 | — | — | 1 | 5.41 |
| CHEMBL5566824 | — | — | 1 | 5.38 |
| CHEMBL5570835 | — | — | 1 | 5.37 |
| CHEMBL5572725 | — | — | 1 | 5.34 |
| CHEMBL5573907 | — | — | 1 | 5.28 |
| CHEMBL5572509 | — | — | 1 | 5.18 |
| CHEMBL5568800 | — | — | 1 | 5.10 |
| CHEMBL5574488 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591844 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5574487 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL5572354 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL5572615 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5564176 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5570584 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5572391 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL5569053 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL5589959 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5575016 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5571190 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5572496 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL5573484 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5566260 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL5570489 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3621411 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL5591928 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL5572839 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5565618 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5591544 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5575608 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL5564184 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL5573289 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL5566824 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL5570835 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL5572725 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL5573907 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL5572509 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5568800 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL5574488 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL3621412 | — | IC50 | = | 13340.0 | nM | 4.88 |
| CHEMBL5563452 | — | IC50 | = | 18680.0 | nM | 4.73 |
| CHEMBL16901 | HONOKIOL | IC50 | = | 41420.0 | nM | 4.38 |
| CHEMBL5573299 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5567453 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL1485211 | — | IC50 | > | 60000.0 | nM | - |