Assay Detail
Functional
CHEMBL5543646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human EBC-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EBC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.33 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188267 | CAPMATINIB | 4.0 | 1 | 8.92 |
| CHEMBL5565630 | — | — | 1 | 5.74 |
| CHEMBL5574768 | — | — | 1 | - |
| CHEMBL5569554 | — | — | 1 | - |
| CHEMBL5572673 | — | — | 1 | - |
| CHEMBL5594055 | — | — | 1 | - |
| CHEMBL5570772 | — | — | 1 | - |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188267 | CAPMATINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5565630 | — | IC50 | = | 1805.7 | nM | 5.74 |
| CHEMBL5574768 | — | IC50 | - | — | - | |
| CHEMBL5569554 | — | IC50 | - | — | - | |
| CHEMBL5572673 | — | IC50 | - | — | - | |
| CHEMBL5594055 | — | IC50 | - | — | - | |
| CHEMBL5570772 | — | IC50 | - | — | - | |
| CHEMBL3809489 | BEMCENTINIB | IC50 | - | — | - |