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Assay Detail

CHEMBL5543879

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Binding
Inhibition of soybean 15-LOX
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.
Elzahhar PA, Orioli R, Hassan NW, Gobbi S, Belluti F, Labib HF, El-Yazbi AF, Nassra R, Belal ASF, Bisi A.
Eur J Med Chem (2024) 266 : 116138 -116138
PubMed 38219658 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.49 5.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5566175 1 5.76
CHEMBL5574361 1 5.62
CHEMBL2234942 1 5.56
CHEMBL5579684 1 5.52
CHEMBL5564416 1 5.49
CHEMBL50 QUERCETIN 3.0 1 5.48
CHEMBL5591853 1 5.39
CHEMBL5569084 1 5.37
CHEMBL5565667 1 5.35
CHEMBL5564555 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5566175 IC50 = 1720.0 nM 5.76
CHEMBL5574361 IC50 = 2390.0 nM 5.62
CHEMBL2234942 IC50 = 2770.0 nM 5.56
CHEMBL5579684 IC50 = 3050.0 nM 5.52
CHEMBL5564416 IC50 = 3250.0 nM 5.49
CHEMBL50 QUERCETIN IC50 = 3340.0 nM 5.48
CHEMBL5591853 IC50 = 4080.0 nM 5.39
CHEMBL5569084 IC50 = 4310.0 nM 5.37
CHEMBL5565667 IC50 = 4440.0 nM 5.35
CHEMBL5564555 IC50 = 4590.0 nM 5.34