Assay Detail
Binding
CHEMBL5543880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human mPGE2S1 using PGH2 as substrate measured after 5 mins by ELISA method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.28 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574361 | — | — | 1 | 5.55 |
| CHEMBL2234942 | — | — | 1 | 5.43 |
| CHEMBL5566175 | — | — | 1 | 5.39 |
| CHEMBL5579684 | — | — | 1 | 5.31 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574361 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2234942 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5566175 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5579684 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL118 | CELECOXIB | IC50 | = | 20100.0 | nM | 4.70 |