Assay Detail
Functional
CHEMBL5543901
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Antiplatelet activity in human platelets assessed as inhibition of arachidonic acid-induced platelet aggregation measured after 2 mins by turbidimetric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.15 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572292 | — | — | 1 | 6.16 |
| CHEMBL5569710 | — | — | 1 | 6.00 |
| CHEMBL5573862 | — | — | 1 | 5.60 |
| CHEMBL5572619 | — | — | 1 | 4.53 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 4.44 |
| CHEMBL5572914 | — | — | 1 | 4.14 |
| CHEMBL5567378 | — | — | 1 | - |
| CHEMBL5579661 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572292 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5569710 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5573862 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5572619 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL25 | ASPIRIN | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL5572914 | — | IC50 | = | 72100.0 | nM | 4.14 |
| CHEMBL5567378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5579661 | — | IC50 | > | 100000.0 | nM | - |