Assay Detail
Functional
CHEMBL5543918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 Wuhan/WIV04/2020 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect incubated for 6 to 7 days by microscopic analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.97 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5565757 | — | — | 1 | 7.10 |
| CHEMBL5594341 | — | — | 1 | 7.05 |
| CHEMBL5589813 | — | — | 1 | 6.80 |
| CHEMBL5576036 | — | — | 1 | 6.60 |
| CHEMBL5574506 | — | — | 1 | 6.57 |
| CHEMBL5070941 | — | — | 1 | 6.31 |
| CHEMBL5591434 | — | — | 1 | 5.62 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.43 |
| CHEMBL5563602 | — | — | 1 | 5.37 |
| CHEMBL4650320 | MOLNUPIRAVIR | 3.0 | 1 | 5.37 |
| CHEMBL5564969 | — | — | 1 | 5.32 |
| CHEMBL5572122 | — | — | 1 | 5.06 |
| CHEMBL5569237 | — | — | 1 | 4.99 |
| CHEMBL5570567 | — | — | 1 | - |
| CHEMBL5566215 | — | — | 1 | - |
| CHEMBL5592679 | — | — | 1 | - |
| CHEMBL5574180 | — | — | 1 | - |
| CHEMBL5566703 | — | — | 1 | - |
| CHEMBL5575599 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5565757 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5594341 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5589813 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5576036 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5574506 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5070941 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5591434 | — | EC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL5563602 | — | EC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4650320 | MOLNUPIRAVIR | EC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5564969 | — | EC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL5572122 | — | EC50 | = | 8710.0 | nM | 5.06 |
| CHEMBL5569237 | — | EC50 | = | 10330.0 | nM | 4.99 |
| CHEMBL5570567 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL5566215 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5592679 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5574180 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL5566703 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5575599 | — | EC50 | > | 100000.0 | nM | - |