Assay Detail
Binding
CHEMBL5543934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ULK1 kinase domain (1 to 283 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 cells preincubated for 20 mins in presence of ATP followed by 33P-ATP addition and measured after 2 hrs by radiometric hotspot kinase assay
44
Total Activities
44
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.30 | 8.70 |
| pIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571896 | — | — | 1 | 8.70 |
| CHEMBL5564752 | — | — | 1 | 8.70 |
| CHEMBL5569162 | — | — | 1 | 8.70 |
| CHEMBL5570377 | — | — | 1 | 8.70 |
| CHEMBL5563000 | — | — | 1 | 8.50 |
| CHEMBL5572614 | — | — | 1 | 8.50 |
| CHEMBL5590601 | — | — | 1 | 8.40 |
| CHEMBL5571775 | — | — | 1 | 8.30 |
| CHEMBL5573979 | — | — | 1 | 8.30 |
| CHEMBL5591974 | — | — | 1 | 8.30 |
| CHEMBL5591655 | — | — | 1 | 8.30 |
| CHEMBL5574119 | — | — | 1 | 8.10 |
| CHEMBL5579740 | — | — | 1 | 8.00 |
| CHEMBL5592149 | — | — | 1 | 7.80 |
| CHEMBL5571213 | — | — | 1 | 7.80 |
| CHEMBL5574962 | — | — | 1 | 7.80 |
| CHEMBL5563074 | — | — | 1 | 7.80 |
| CHEMBL5591789 | — | — | 1 | 7.60 |
| CHEMBL5575328 | — | — | 1 | 7.50 |
| CHEMBL5569586 | — | — | 1 | 7.40 |
| CHEMBL5564953 | — | — | 1 | 7.40 |
| CHEMBL5569949 | — | — | 1 | 7.20 |
| CHEMBL5564550 | — | — | 1 | 7.10 |
| CHEMBL5568876 | — | — | 1 | 7.10 |
| CHEMBL5575719 | — | — | 1 | 7.10 |
| CHEMBL5565244 | — | — | 1 | 7.00 |
| CHEMBL5571098 | — | — | 1 | 7.00 |
| CHEMBL5569436 | — | — | 1 | 6.90 |
| CHEMBL5594421 | — | — | 1 | 6.90 |
| CHEMBL5574661 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571896 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5564752 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5569162 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5570377 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL5563000 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5572614 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5590601 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL5571775 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL5573979 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL5591974 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL5591655 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL5574119 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5579740 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5563074 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5574962 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5592149 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5571213 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5591789 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5575328 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5569586 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5564953 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5569949 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5564550 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5575719 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5568876 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5565244 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5571098 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5569436 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5594421 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5574661 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5574092 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5566944 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5562596 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5568845 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5567142 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL5590760 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL5574020 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL5570235 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL5573413 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL5594182 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4744680 | — | pIC50 | - | — | - | |
| CHEMBL5590352 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5575955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5590861 | — | IC50 | > | 10000.0 | nM | - |