Assay Detail
Binding
CHEMBL5543935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NanoLuc fused ULK1 (unknown origin) transfected in NCI-H2030 cells incubated for 2 hrs by tracer K10 based NanoBRET assay
44
Total Activities
44
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H2030 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pIC50 | 26 | - | - |
| IC50 | 18 | 7.25 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572614 | — | — | 1 | 8.10 |
| CHEMBL5570377 | — | — | 1 | 8.00 |
| CHEMBL5564752 | — | — | 1 | 8.00 |
| CHEMBL5573979 | — | — | 1 | 7.90 |
| CHEMBL5571775 | — | — | 1 | 7.70 |
| CHEMBL5590601 | — | — | 1 | 7.60 |
| CHEMBL5569586 | — | — | 1 | 7.40 |
| CHEMBL5563000 | — | — | 1 | 7.40 |
| CHEMBL5569162 | — | — | 1 | 7.30 |
| CHEMBL5579740 | — | — | 1 | 7.20 |
| CHEMBL5591974 | — | — | 1 | 7.10 |
| CHEMBL4744680 | — | — | 1 | 7.00 |
| CHEMBL5574962 | — | — | 1 | 6.90 |
| CHEMBL5591655 | — | — | 1 | 6.70 |
| CHEMBL5574119 | — | — | 1 | 6.70 |
| CHEMBL5591789 | — | — | 1 | 6.60 |
| CHEMBL5563074 | — | — | 1 | 6.50 |
| CHEMBL5592149 | — | — | 1 | 6.40 |
| CHEMBL5566944 | — | — | 1 | - |
| CHEMBL5574020 | — | — | 1 | - |
| CHEMBL5571098 | — | — | 1 | - |
| CHEMBL5590352 | — | — | 1 | - |
| CHEMBL5569436 | — | — | 1 | - |
| CHEMBL5564550 | — | — | 1 | - |
| CHEMBL5567142 | — | — | 1 | - |
| CHEMBL5568876 | — | — | 1 | - |
| CHEMBL5574661 | — | — | 1 | - |
| CHEMBL5575719 | — | — | 1 | - |
| CHEMBL5575328 | — | — | 1 | - |
| CHEMBL5564953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572614 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5570377 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5564752 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5573979 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5571775 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5590601 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5569586 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5563000 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5569162 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5579740 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5591974 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4744680 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5574962 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5591655 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5574119 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5591789 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5563074 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL5592149 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5594421 | — | pIC50 | - | — | - | |
| CHEMBL5571896 | — | pIC50 | - | — | - | |
| CHEMBL5590861 | — | pIC50 | - | — | - | |
| CHEMBL5590760 | — | pIC50 | - | — | - | |
| CHEMBL5573413 | — | pIC50 | - | — | - | |
| CHEMBL5570235 | — | pIC50 | - | — | - | |
| CHEMBL5571213 | — | pIC50 | - | — | - | |
| CHEMBL5594182 | — | pIC50 | - | — | - | |
| CHEMBL5574092 | — | pIC50 | - | — | - | |
| CHEMBL5569949 | — | pIC50 | - | — | - | |
| CHEMBL5562596 | — | pIC50 | - | — | - | |
| CHEMBL5568845 | — | pIC50 | - | — | - | |
| CHEMBL5575955 | — | pIC50 | - | — | - | |
| CHEMBL5565244 | — | pIC50 | - | — | - | |
| CHEMBL5564953 | — | pIC50 | - | — | - | |
| CHEMBL5575328 | — | pIC50 | - | — | - | |
| CHEMBL5575719 | — | pIC50 | - | — | - | |
| CHEMBL5574661 | — | pIC50 | - | — | - | |
| CHEMBL5568876 | — | pIC50 | - | — | - | |
| CHEMBL5567142 | — | pIC50 | - | — | - | |
| CHEMBL5564550 | — | pIC50 | - | — | - | |
| CHEMBL5569436 | — | pIC50 | - | — | - | |
| CHEMBL5590352 | — | pIC50 | - | — | - | |
| CHEMBL5571098 | — | pIC50 | - | — | - | |
| CHEMBL5574020 | — | pIC50 | - | — | - | |
| CHEMBL5566944 | — | pIC50 | - | — | - |