Assay Detail
Functional
CHEMBL5543967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autophagy in trametinib treated human NCI-H2030 cells assessed as inhibition of ATG13 phosphorylation at Ser318 residue incubated for 24 hrs by Western blot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2030 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.32 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570377 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570377 | — | EC50 | = | 48.0 | nM | 7.32 |