Assay Detail
Functional
CHEMBL5543971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H2030 cells harboring KRAS G12C mutant assessed as inhibition of cell growth incubated for 72 hrs by celltiter-glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2030 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.50 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570377 | — | — | 1 | 5.50 |
| CHEMBL2103875 | TRAMETINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570377 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2103875 | TRAMETINIB | IC50 | > | 50000.0 | nM | - |