Assay Detail
Functional
CHEMBL5544196
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Antiproliferative activity against human NCI-H1373 cells incubated for 4 days by luminescence cell viability assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1373 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.55 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568745 | — | — | 1 | 8.60 |
| CHEMBL5568973 | — | — | 1 | 8.29 |
| CHEMBL5572156 | — | — | 1 | 8.19 |
| CHEMBL5569182 | — | — | 1 | 7.80 |
| CHEMBL5565268 | — | — | 1 | 7.71 |
| CHEMBL5564709 | — | — | 1 | 7.70 |
| CHEMBL5575932 | — | — | 1 | 7.68 |
| CHEMBL5572774 | — | — | 1 | 7.35 |
| CHEMBL5095043 | ATAMPARIB | 1.0 | 1 | 7.34 |
| CHEMBL5575060 | — | — | 1 | 7.22 |
| CHEMBL5574187 | — | — | 1 | 6.46 |
| CHEMBL5565931 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568745 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5568973 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5572156 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5569182 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5565268 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL5564709 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5575932 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5572774 | — | IC50 | = | 44.7 | nM | 7.35 |
| CHEMBL5095043 | ATAMPARIB | IC50 | = | 45.3 | nM | 7.34 |
| CHEMBL5575060 | — | IC50 | = | 60.5 | nM | 7.22 |
| CHEMBL5574187 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL5565931 | — | IC50 | = | 499.0 | nM | 6.30 |