Assay Detail
Functional
CHEMBL5544201
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Upregulation of IFN-beta expression in mouse RAW264.7 cells incubated for 1 day by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.34 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568745 | — | — | 1 | 7.34 |
| CHEMBL5575932 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568745 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5575932 | — | EC50 | = | 47.0 | nM | 7.33 |