Assay Detail
Functional
CHEMBL5544528
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication pre-infected with cells for 1 hr followed by compound treatment and measured after 3 days by RT-qPCR analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.38 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569828 | — | — | 1 | 7.46 |
| CHEMBL5574604 | — | — | 1 | 6.58 |
| CHEMBL5590149 | — | — | 1 | 6.57 |
| CHEMBL5563071 | — | — | 1 | 6.54 |
| CHEMBL5589941 | — | — | 1 | 5.80 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 5.70 |
| CHEMBL5202626 | — | — | 1 | 5.64 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 5.50 |
| CHEMBL5569267 | — | — | 1 | 5.47 |
| CHEMBL5178656 | — | — | 1 | 5.40 |
| CHEMBL5570219 | — | — | 1 | 4.77 |
| CHEMBL5570206 | — | — | 1 | 4.57 |
| CHEMBL5563372 | — | — | 1 | 4.53 |
| CHEMBL5593536 | — | — | 1 | 4.51 |
| CHEMBL5594793 | — | — | 1 | 4.40 |
| CHEMBL5570083 | — | — | 1 | 4.00 |
| CHEMBL5563277 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569828 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5574604 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5590149 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5563071 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5589941 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5202626 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5569267 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5178656 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5570219 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5570206 | — | EC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL5563372 | — | EC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL5593536 | — | EC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL5594793 | — | EC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL5570083 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5563277 | — | EC50 | = | 100000.0 | nM | 4.00 |