Assay Detail
Binding
CHEMBL5545047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human alpha7 nAChR expressed in xenopus laevis oocytes assessed as potentiation of acetylcholine induced channel current amplitude by measuring acetylcholine EC50 at 10 uM preincubated for 2 mins followed by co-application with acetylcholine for 20 sec by two-electrode voltage clamp recording method (Rvb = 270.14 +/- 75.06 uM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric Activation of α7 Nicotinic Acetylcholine Receptors by Novel 2-Arylamino-thiazole-5-carboxylic Acid Amide Derivatives for the Improvement of Cognitive Deficits in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 4.21 | 4.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569159 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569159 | — | EC50 | = | 61190.0 | nM | 4.21 |