Assay Detail
Binding
CHEMBL5545546
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Binding affinity to p300 (unknown origin) assessed as dissociation constant by ITC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.02 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097025 | — | — | 1 | 8.92 |
| CHEMBL4076748 | — | — | 1 | 8.89 |
| CHEMBL3622373 | — | — | 1 | 7.50 |
| CHEMBL3774655 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097025 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4076748 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL3622373 | — | Kd | = | 32.0 | nM | 7.50 |
| CHEMBL3774655 | — | Kd | = | 167.0 | nM | 6.78 |