Assay Detail
Functional
CHEMBL5545630
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Antiproliferative activity against human 22Rv1 cells assessed as cell growth inhibition incubated for 4 days by celtiter-glo luminescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.22 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5564627 | — | — | 1 | 8.43 |
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 6.74 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | 1.0 | 1 | 6.50 |
| CHEMBL4076748 | — | — | 1 | - |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5564627 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4785363 | INOBRODIB | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL4076748 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | > | 1000.0 | nM | - |