Assay Detail
Functional
CHEMBL5546059
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Antiproliferative activity against human HCC827 cells by CellTiter-Glo assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel 5,6-Dihydro-4<i>H</i>-pyrido[2,3,4-<i>de</i>]quinazoline Irreversible Inhibitors Targeting Both Wild-Type and A775_G776insYVMA Mutated HER2 Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.13 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 9.64 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.64 |
| CHEMBL5572504 | — | — | 1 | 9.62 |
| CHEMBL5572670 | — | — | 1 | 9.43 |
| CHEMBL5569244 | — | — | 1 | 9.17 |
| CHEMBL5574232 | — | — | 1 | 9.09 |
| CHEMBL5566736 | — | — | 1 | 7.78 |
| CHEMBL5591930 | — | — | 1 | 7.77 |
| CHEMBL5569696 | — | — | 1 | 7.65 |
| CHEMBL5575930 | — | — | 1 | 7.64 |
| CHEMBL5566473 | — | — | 1 | 7.63 |
| CHEMBL5591255 | — | — | 1 | 7.60 |
| CHEMBL5567355 | — | — | 1 | 7.51 |
| CHEMBL5566173 | — | — | 1 | 7.50 |
| CHEMBL5572514 | — | — | 1 | 7.45 |
| CHEMBL5570443 | — | — | 1 | 7.37 |
| CHEMBL5574206 | — | — | 1 | 7.28 |
| CHEMBL5563672 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL939 | GEFITINIB | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL5572504 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5572670 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL5569244 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL5574232 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL5566736 | — | IC50 | = | 16.48 | nM | 7.78 |
| CHEMBL5591930 | — | IC50 | = | 16.87 | nM | 7.77 |
| CHEMBL5569696 | — | IC50 | = | 22.29 | nM | 7.65 |
| CHEMBL5575930 | — | IC50 | = | 22.72 | nM | 7.64 |
| CHEMBL5566473 | — | IC50 | = | 23.16 | nM | 7.63 |
| CHEMBL5591255 | — | IC50 | = | 25.27 | nM | 7.60 |
| CHEMBL5567355 | — | IC50 | = | 30.56 | nM | 7.51 |
| CHEMBL5566173 | — | IC50 | = | 32.02 | nM | 7.50 |
| CHEMBL5572514 | — | IC50 | = | 35.86 | nM | 7.45 |
| CHEMBL5570443 | — | IC50 | = | 42.82 | nM | 7.37 |
| CHEMBL5574206 | — | IC50 | = | 52.76 | nM | 7.28 |
| CHEMBL5563672 | — | IC50 | = | 272.0 | nM | 6.57 |