Assay Detail
Binding
CHEMBL5546191
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Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.30 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571568 | — | — | 1 | 8.60 |
| CHEMBL5574976 | — | — | 1 | 8.21 |
| CHEMBL5569981 | — | — | 1 | 7.92 |
| CHEMBL5571377 | — | — | 1 | 7.89 |
| CHEMBL5591595 | — | — | 1 | 7.85 |
| CHEMBL5579682 | — | — | 1 | 7.82 |
| CHEMBL5590796 | — | — | 1 | 7.82 |
| CHEMBL5593998 | — | — | 1 | 7.41 |
| CHEMBL5575532 | — | — | 1 | 7.41 |
| CHEMBL5574193 | — | — | 1 | 7.37 |
| CHEMBL5574769 | — | — | 1 | 7.20 |
| CHEMBL5593039 | — | — | 1 | 7.16 |
| CHEMBL5590134 | — | — | 1 | 6.60 |
| CHEMBL5567100 | — | — | 1 | 6.40 |
| CHEMBL5590151 | — | — | 1 | 5.77 |
| CHEMBL5570666 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571568 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5574976 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5569981 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5571377 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5591595 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5579682 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5590796 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5593998 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5575532 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5574193 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5574769 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5593039 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5590134 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5567100 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5590151 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5570666 | — | IC50 | = | 3700.0 | nM | 5.43 |