Assay Detail
Functional
CHEMBL5547051
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CT26 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.78 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570653 | — | — | 1 | 5.39 |
| CHEMBL5573665 | — | — | 1 | 5.28 |
| CHEMBL5575934 | — | — | 1 | 5.05 |
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 4.73 |
| CHEMBL5570510 | — | — | 1 | 4.71 |
| CHEMBL5575434 | — | — | 1 | 4.56 |
| CHEMBL5574154 | — | — | 1 | 4.51 |
| CHEMBL5191459 | — | — | 1 | 4.48 |
| CHEMBL5575062 | — | — | 1 | 4.34 |
| CHEMBL5566235 | — | — | 1 | - |
| CHEMBL5574170 | — | — | 1 | - |
| CHEMBL5573849 | — | — | 1 | - |
| CHEMBL5575262 | — | — | 1 | - |
| CHEMBL5594841 | — | — | 1 | - |
| CHEMBL5573920 | — | — | 1 | - |
| CHEMBL5573858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570653 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5573665 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5575934 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4439259 | AZD-7648 | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL5570510 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL5575434 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL5574154 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL5191459 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL5575062 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL5566235 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5574170 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5573849 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5575262 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5594841 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5573920 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5573858 | — | IC50 | > | 50000.0 | nM | - |