Assay Detail
Functional
CHEMBL5547055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs in presence of doxorubicin by CCK-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.90 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570653 | — | — | 1 | 5.31 |
| CHEMBL5573665 | — | — | 1 | 5.19 |
| CHEMBL5575934 | — | — | 1 | 5.12 |
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 4.94 |
| CHEMBL5191459 | — | — | 1 | 4.69 |
| CHEMBL5575434 | — | — | 1 | 4.68 |
| CHEMBL5574154 | — | — | 1 | 4.66 |
| CHEMBL5570510 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570653 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5573665 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5575934 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4439259 | AZD-7648 | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5191459 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL5575434 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL5574154 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL5570510 | — | IC50 | = | 26900.0 | nM | 4.57 |