Assay Detail
Binding
CHEMBL5547423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from human 5-HT2C receptor expressed in HEK293 cell membrane incubated for 90 mins by microbeta liquid scintillation counting method
28
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT<sub>2</sub> Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.63 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5589604 | — | — | 2 | 8.16 |
| CHEMBL5563542 | — | — | 2 | 8.05 |
| CHEMBL5569144 | — | — | 2 | 7.97 |
| CHEMBL5573972 | — | — | 2 | 7.96 |
| CHEMBL5574455 | — | — | 2 | 7.89 |
| CHEMBL5565116 | — | — | 2 | 7.80 |
| CHEMBL5572387 | — | — | 2 | 7.68 |
| CHEMBL5594012 | — | — | 2 | 7.59 |
| CHEMBL5584114 | — | — | 2 | 7.59 |
| CHEMBL5566251 | — | — | 2 | 7.18 |
| CHEMBL5573377 | — | — | 2 | 7.09 |
| CHEMBL5572320 | — | — | 2 | 7.08 |
| CHEMBL5566821 | — | — | 1 | 7.02 |
| CHEMBL5570285 | — | — | 1 | - |
| CHEMBL5570258 | — | — | 1 | - |
| CHEMBL5570359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5589604 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL5589604 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL5563542 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL5563542 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL5569144 | — | Ki | = | 10.72 | nM | 7.97 |
| CHEMBL5573972 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5569144 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5574455 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5574455 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL5565116 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL5565116 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL5572387 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5572387 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL5573972 | — | Ki | = | 21.38 | nM | 7.67 |
| CHEMBL5594012 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL5584114 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL5584114 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL5594012 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL5566251 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL5566251 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL5573377 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL5573377 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL5572320 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL5572320 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL5566821 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL5570285 | — | Ki | - | — | - | |
| CHEMBL5570359 | — | Ki | - | — | - | |
| CHEMBL5570258 | — | Ki | - | — | - |