Assay Detail
Functional
CHEMBL5547455
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Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as IP2 production measured after 30 mins incubation by HTRF assay
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT<sub>2</sub> Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.04 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566821 | — | — | 2 | 7.04 |
| CHEMBL6616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566821 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5566821 | — | EC50 | = | 91.2 | nM | 7.04 |
| CHEMBL6616 | — | EC50 | - | — | - |