Assay Detail
Binding
CHEMBL5548029
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Inhibition of full length nanoluc-fused FGFR2 transfected in HEK293T cells assessed as target engagement incubated for 3 hrs in presence of K10 tracer by Nano BRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S<sub>N</sub>Ar Electrophiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.81 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575075 | — | — | 1 | 6.06 |
| CHEMBL5571683 | — | — | 1 | 5.89 |
| CHEMBL4068896 | — | — | 1 | 5.48 |
| CHEMBL5570033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575075 | — | EC50 | = | 867.0 | nM | 6.06 |
| CHEMBL5571683 | — | EC50 | = | 1287.0 | nM | 5.89 |
| CHEMBL4068896 | — | EC50 | = | 3304.0 | nM | 5.48 |
| CHEMBL5570033 | — | EC50 | > | 10000.0 | nM | - |