Assay Detail
Binding
CHEMBL5548272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human Casein lysing protease P (HsClpP) assessed as increase in peptidase activity using fluorescent peptide AC-WLA-AMC as substrate measured after 2 hrs by SDS-PAGE/Kamus brilliant blue assay
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CHEMBL4523305) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 60 | 5.90 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568993 | — | — | 1 | 6.29 |
| CHEMBL5566864 | — | — | 1 | 6.28 |
| CHEMBL5594686 | — | — | 1 | 6.21 |
| CHEMBL5567372 | — | — | 1 | 6.21 |
| CHEMBL5595003 | — | — | 1 | 6.10 |
| CHEMBL5562827 | — | — | 1 | 6.09 |
| CHEMBL5583555 | — | — | 1 | 6.06 |
| CHEMBL5573326 | — | — | 1 | 6.02 |
| CHEMBL5574664 | — | — | 1 | 6.00 |
| CHEMBL5595420 | — | — | 1 | 6.00 |
| CHEMBL5569571 | — | — | 1 | 5.96 |
| CHEMBL5563416 | — | — | 1 | 5.96 |
| CHEMBL5571975 | — | — | 1 | 5.92 |
| CHEMBL5572915 | — | — | 1 | 5.91 |
| CHEMBL5583540 | — | — | 1 | 5.87 |
| CHEMBL5592541 | — | — | 1 | 5.87 |
| CHEMBL5584180 | — | — | 1 | 5.87 |
| CHEMBL5569215 | — | — | 1 | 5.85 |
| CHEMBL5196543 | — | — | 1 | 5.72 |
| CHEMBL5571551 | — | — | 1 | 5.71 |
| CHEMBL5592169 | — | — | 1 | 5.71 |
| CHEMBL5571112 | — | — | 1 | 5.70 |
| CHEMBL5570877 | — | — | 1 | 5.70 |
| CHEMBL5571963 | — | — | 1 | 5.68 |
| CHEMBL5573621 | — | — | 1 | 5.68 |
| CHEMBL5571042 | — | — | 1 | 5.65 |
| CHEMBL5572595 | — | — | 1 | 5.65 |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | 5.62 |
| CHEMBL5571561 | — | — | 1 | - |
| CHEMBL5574304 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568993 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5566864 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5567372 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5594686 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5595003 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5562827 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5583555 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5573326 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5574664 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5595420 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5569571 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5563416 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5571975 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL5572915 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5584180 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5592541 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5583540 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5569215 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5196543 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5571551 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5592169 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5571112 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL5570877 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL5571963 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5573621 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5571042 | — | EC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL5572595 | — | EC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4297310 | DORDAVIPRONE | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5566322 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5571575 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5574707 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5566043 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5566615 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5574796 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5576009 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5573185 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5571126 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5574931 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5593185 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5569088 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5593791 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5572820 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5573645 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5565457 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5571254 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5590733 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5563985 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5565900 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5574304 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5571561 | — | EC50 | > | 10000.0 | nM | - |