Assay Detail
Binding
CHEMBL5548277
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human Casein lysing protease P (HsClpP) assessed as proteolytic activity by measuring alpha-casein hydrolysis measured after 2 hrs incubation by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CHEMBL4523305) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.92 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595003 | — | — | 1 | 6.01 |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595003 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4297310 | DORDAVIPRONE | EC50 | = | 1490.0 | nM | 5.83 |