Assay Detail
Functional
CHEMBL5548525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS CoV-2 GFP infected in african green monkey Vero cells at 0.05 MOI assessed as reduction in viral titer incubated for 48 hrs by plaque assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.19 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132586 | — | — | 1 | 6.84 |
| CHEMBL304784 | — | — | 1 | 6.70 |
| CHEMBL5566430 | — | — | 1 | 6.46 |
| CHEMBL406405 | — | — | 1 | 6.39 |
| CHEMBL92708 | CALPEPTIN | — | 1 | 5.93 |
| CHEMBL288365 | — | — | 1 | 5.88 |
| CHEMBL286722 | — | — | 1 | 5.78 |
| CHEMBL5595143 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132586 | — | EC50 | = | 145.6 | nM | 6.84 |
| CHEMBL304784 | — | EC50 | = | 198.0 | nM | 6.70 |
| CHEMBL5566430 | — | EC50 | = | 350.8 | nM | 6.46 |
| CHEMBL406405 | — | EC50 | = | 411.0 | nM | 6.39 |
| CHEMBL92708 | CALPEPTIN | EC50 | = | 1183.0 | nM | 5.93 |
| CHEMBL288365 | — | EC50 | = | 1334.0 | nM | 5.88 |
| CHEMBL286722 | — | EC50 | = | 1651.0 | nM | 5.78 |
| CHEMBL5595143 | — | EC50 | = | 2784.0 | nM | 5.55 |