Assay Detail
Functional
CHEMBL5548618
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Antiallergic activity in rat RBL-2H3 cell model assessed as inhibition rate of IgE-mediated degranulation in by measuring beta-aminosidase
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.86 | 5.17 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5565041 | — | — | 2 | 5.17 |
| CHEMBL517026 | — | — | 1 | 4.87 |
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5565041 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL517026 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL534 | KETOTIFEN | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL5565041 | — | Inhibition | - | % | - |